Extended Data Fig. 10: Relationship between the effects of the genetic instruments on VAT^ and their effects on disease.

Each panel shows the relationship between the effects on VAT^ and the effects on disease of the n = 44 nearly independent genetic instruments (Supplementary Table 21). Error bars denote the 95% CI (normal approximation) of each effect estimate. Females are denoted in black, while males are denoted in red. Pleiotropic outliers identified by the GSMR analysis that were removed before estimation of the causal effects are shown in gray (Supplementary Table 22). An observed slope is indicative of a causal relationship between VAT^ and disease that is unbiased by confounding. The dashed lines denote the estimated log[OR] values by the gsmr package (Table 1). Note the different scales of the y axes.