Extended Data Fig. 6: Results from the luciferase assay in HepG2 cells.

For each set of alleles, the box plots represent the median, interquartile range, and minimum and maximum values of all replicates, except for outliers, which are represented as individual points. The total number of replicates of each plasmid is given by the number of independent plasmid extractions multiplied by the number of independent transfections. The P values (two-sided t-test) represent pairwise differences in means, either for the control plasmid (pGL4.10 or pGL4.23) without any insert versus the same plasmid with one of the fragments inserted, or for the two plasmids with fragments, with different alleles inserted. In the names, the subscripts _E and _P indicate whether the fragment was cloned as an enhancer (_E) or promoter (_P) element, with _P1 and _P2 representing two different fragments in the same promoter region. The last part of the names represents the alleles of the SNPs that were targeted by each fragment (see Supplementary Table 14). Two to three independent plasmid extractions and transfections were performed, with each transfection being replicated three times.