Extended Data Fig. 4: Neonatal systemic administration of AAV-µUtro eliminates active proteolysis, apoptosis and centrally nucleated myofibers in eight-week-old mdx limb muscle.
From: Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models
a, Representative immunofluorescence staining with MuRF1 (top panel) and TUNEL (bottom panel). Scale bar, 50 μm. b, Table summarizing mean and s.d. of centrally nucleated myofibers (Fig. 1d), MuRF1, TUNEL and embryonic positive myofibers (for example, see Fig. 1a) in mdx + PBS, mdx + AAV-µUtro and wild type + PBS. Data are presented as mean ± s.d.
