Extended Data Fig. 8: GWAS of adipsin levels in the Framingham Cohort. | Nature Medicine

Extended Data Fig. 8: GWAS of adipsin levels in the Framingham Cohort.

From: Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

Extended Data Fig. 8

A genome-wide association study of adipsin levels was conducted among n = 6791 individuals with available genetic data using an additive genetic model (t statistic). (a) A quintile-quintile plot of the observed and expected P-values. Each dot represents observed data while the solid line represents the null hypothesis of no association. (b) A regional plot of the sentinel SNP (rs2930902) associated with elevated plasma adipsin level is housed intronically within the MED16. Other significant cis-SNPs are also shown.

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