Extended Data Fig. 9: Significant cis variant SNPs with phenotypic association, eQTL analysis, and associated metabolites from published databases. | Nature Medicine

Extended Data Fig. 9: Significant cis variant SNPs with phenotypic association, eQTL analysis, and associated metabolites from published databases.

From: Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

Extended Data Fig. 9

The lead SNP on chromosome 19 rs2930902 is an intron variant in the MED16 locus and is associated with type 2 diabetes. Tissue specific cis-eQTL’s reveal that this SNP is significantly associated with adipsin expression in a number of tissues but notably in subcutaneous (but not visceral) adipose tissue. Moreover, the same SNP is associated with known branch chain amino acid metabolites (glycine and valine) known to predict incident type 2 diabetes mellitus. Three additional SNPs associated with adipisin expression are shown.

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