Fig. 1: Genomic evidence for L. rhamnosus transmission from probiotic capsule to the blood of patients. | Nature Medicine

Fig. 1: Genomic evidence for L. rhamnosus transmission from probiotic capsule to the blood of patients.

From: Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients

Fig. 1

a, Schematic for whole-genome sequencing of L. rhamnosus probiotic isolates, blood isolates from ICU patients (n = 6) receiving probiotics, and blood isolates from non-ICU patients (n = 4) who were not receiving probiotics. Black circles represent sequencing of multiple individual colonies for each probiotic batch but a single colony for each blood isolate. b, Similarity between L. rhamnosus isolates and available reference genomes are shown as the fraction of reads aligned to each reference. Isolates are identified by their source: four representative isolates from each of three probiotic product batches, the six blood isolates from patients receiving probiotics, and the four blood L. rhamnosus isolates from patients not receiving probiotics. c, Phylogenetic analysis of all 54 sequenced LGG isolates: 16 isolates from each of three separate probiotic batches (blue), and the six blood isolates from Patients R1 to R6 (magenta).

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