Extended Data Fig. 6: The effects of mean HLA-I evolutionary divergence and tumor mutational burden are independent of cancer type and drug class.
From: Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
a, Multivariable Cox proportional-hazards model including mean HED and other clinical variables using all patients. Data show independent effect of mean HED in predicting response to ICI. Drug class P = 8.14e-06. P values calculated using two-sided log-rank test. Horizontal lines indicate 95% confidence interval. b, Multivariable Cox proportional-hazards model including mean HED and other clinical variables using patients fully heterozygous at HLA-I. Data show independent effect of mean HED associated with improved survival after ICI therapy. Mean HED P = 7.25e-04; Drug Class P = 9.32e-05. HED and TMB are dichotomized into high (1) and low (0) groups using the top quartile for each variable. P values calculated using two-sided log-rank test. Horizontal lines represent the 95% confidence interval.
