Extended Data Fig. 3: Age correlation of all and mosaic dSNVs.
From: Autism risk in offspring can be assessed through quantification of male sperm mosaicism
a, Plot showing the increase in dSNV number with paternal age at birth, as described previously1,5. Dashed line shows a regression curve demonstrating this dependence (n = 14 trios, adjusted R2 = 0.526, P = 0.0020). b, Plot showing the increase in dSNV number with paternal age at birth for paternal variants only. As expected, this correlation was stronger than for non-phased variants (n = 13 trios, adjusted R2 = 0.736, P = 0.000107). c-d, Plots showing correlation for paternal age and the number of mosaic variants or the mean AF in sperm. Paternal age/the number of mosaic variants (c; n = 14 trios, adjusted R2 = -0.048, P = 0.536) and paternal age/mean AF in sperm (d; n = 14 trios, adjusted R2 = -0.047, P = 0.463) did not show any significant correlation. Adjusted R2, coefficient of determination, and F-statistic nominal P-values are derived from a linear regression model through ordinary least squares. All graphs show individual data points, a regression line, and the 95% CI.
