Extended Data Fig. 6: Association of PPI/dosage and the PPI-related metabolites. | Nature Medicine

Extended Data Fig. 6: Association of PPI/dosage and the PPI-related metabolites.

From: Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Extended Data Fig. 6

The association of dosage of PPI and metabolites were tested by linear regression in Rotterdam Study (n = 700). The PPI-related metabolites were selected in model 3. DDD, defined daily dose of PPI. (/), sample size of user/non-user. Red, positive association, blue, negative association. The depth of the color refers to the association estimates. Asterisks in boxes denote significance after correcting for multiple test (P-value < 0.004). Two-tailed tests were used.

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