Extended Data Fig. 7: Association of specific PPI drugs and the PPI-related metabolites. | Nature Medicine

Extended Data Fig. 7: Association of specific PPI drugs and the PPI-related metabolites.

From: Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Extended Data Fig. 7

The association of PPI drugs (A02BC) and metabolites were tested by linear regression in Rotterdam Study. The PPI-related metabolites were selected in model 3. A02BC01, omeprazole; A02BC02, pantoprazole; A02BC03, lansoprazole; A02BC04, rabeprazole; A02BC05, esomeprazole. (/), sample size of user/non-user. Red, positive association; blue: negative association. The depth of the color refers to the association estimates. Asterisks in boxes denote significance after correcting for multiple test (P-value < 0.004). Two-tailed tests were used.

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