Extended Data Fig. 4: Correlation between drugs.

The correlation matrix of metabolites were performed by Spearman’s correlation (n = 6,631). The first letter of the ATC code is shown preceding the drug name, to identify different categories. Sample size of the drug users and non-users is shown following drug names. The depth of the color refers to the correlation coefficients. Asterisks in boxes denote the positively significant correlations (P-value < 5.9 × 10−4). Two-tailed tests were used.