Extended Data Fig. 10: Relationship between sex and baseline signatures.

a, Box plots comparing the TGSig and SLE-Sig scores in females versus males; here only subjects with CITE-seq data are included to indicate that sex was not a driver of the differences between 10 high and 10 low responders emerged from CITE-seq data analysis (see Fig. 4). Wilcoxon two-tailed p values comparing 11 females and 9 males are shown. For all box plots the center line corresponds to the median value, lower and upper hinges correspond to the first and third quartiles (the 25th and 75th percentiles); lower and upper whiskers extend from the box to the smallest or largest value correspondingly, but no further than 1.5x inter-quantile range. b, Same as (a) but including all high and low responders from original NIH study¹². (day 0: 12 females and 12 males; day -7: 13 females and 11 males; day 70: 11 females and 12 males) c, same as (b) but including middle responders (i.e., all subjects in the study: day 0: 27 females and 16 males; day -7: 30 females and 16 males; day 70: 27 females and 17 males). d, Box plots comparing TGSig scores among low, middle, and high responders in males only (all subjects in the original NIH study¹² used: day 0: 6/4/6 for low/middle/high responders, respectively; day -7: 5/5/6; day 70: 6/5/6). e, same as (d) but in females only (day 0: 5/15/17 for low/middle/high responders, respectively; day -7: 5/17/8; day 70: 5/16/6). All p values shown for two-group comparison were from the Wilcoxon two-tailed test; one-tailed p values shown for three-group comparison were from the Jonckheere trend test (with an a priori alternative hypothesis that the high responders >= middle responders >=low responders).