Extended Data Fig. 1: Plasma viral loads during acute SIV infection and subsequent decay during ART. | Nature Medicine

Extended Data Fig. 1: Plasma viral loads during acute SIV infection and subsequent decay during ART.

From: CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

Extended Data Fig. 1

Viral loads (SIVmac239 RNA copies/mL) were quantified in plasma utilizing RT-qPCR and represented on a logarithmic scale. The terminal measurement (indicated in light red) for each animal indicates the start of ICB therapy (d0 p.t.). Initiation of ICB therapy was dependent on duration of undetectable viremia in plasma. Data sets are grouped based on ICB treatment as follows: (a) VHDUM (control; n=6), black; (b) anti-CTLA-4 mAb (αCTLA-4; n=6), blue; (c) anti-PD-1 mAb (αPD-1; n=6), pink; (d) anti-CTLA-4 plus anti-PD-1 mAb (combined blockade; n=7), red; and (e) anti-CTLA-4/PD-1 mAbdAb (BsAb; n=8), purple. Individual RMs are indicated by shape with closed data points indicating viral reactivation in plasma during subsequent ICB. The vertical dotted line indicates ART initiation (d60 p.i.) and the shaded gray area represents ongoing ART administration. The horizontal dotted line indicates the assay’s limit of detection (≤60 copies/mL) with undetectable events represented as 30 copies/mL.

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