Extended Data Fig. 3: Blockade pharmacokinetics and emergence of anti-drug antibodies. | Nature Medicine

Extended Data Fig. 3: Blockade pharmacokinetics and emergence of anti-drug antibodies.

From: CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

Extended Data Fig. 3

(a) Plasma concentrations (ng/mL) of Co-IR blocking monoclonal antibodies (mAb) were quantified with an antibody capture assay; stratified by treatment group; and represented on a logarithmic scale. Blood was drawn immediately prior to- and 5 mins following ICB administration. (b) Using only blood drawn prior to ICB infusion, the levels of anti-drug antibodies (ECL, electrochemiluminescence) were quantified by MSD assay, which were utilized to calculate the percentage of inhibition. Vertical arrows and dotted lines represent either an ICB infusion or ART interruption, as indicated, with the gray shaded area representing ongoing ART. Individual RMs are indicated by shape with closed data points indicating animals with viral reactivation in plasma.

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