Extended Data Fig. 4: Combined blockade leads to a limited restoration of cytolytic functionality in ICR-expressing CD8+ T cell subsets. | Nature Medicine

Extended Data Fig. 4: Combined blockade leads to a limited restoration of cytolytic functionality in ICR-expressing CD8+ T cell subsets.

From: CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

Extended Data Fig. 4

By flow cytometry, the frequencies of granzyme B+ cells were determined within (a) CTLA-4+PD-1+ and (b) CTLA-4+PD-1- memory CD8+ T cells in LN following the fourth ICB infusion (d28 p.t.). All RMs are color-coded and grouped based on ICB therapy with population sizes as indicated for all analyses: controls (n=6), black; αCTLA-4 (n=6), blue; αPD-1 (n=6), pink; combined blockade (n=7), red; and BsAb (n=8), purple. Averaged data are presented as the mean ± s.e.m. and were analyzed with a two-sided Kruskal-Wallis test with Dunn’s correction for multiple comparisons relative to controls.

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