Extended Data Fig. 7: Applying myeloid differentiation axes to myeloid neoplasms.
From: Multiplexed single-cell morphometry for hematopathology diagnostics
a, Myeloid cells from a healthy control (left column) and four clinical samples with myeloid neoplasms (columns 2-5) plotted on MD axes. Plots are z-colored by expression of the marker in the row label, according to the scale at the bottom left. MD axes are scaled individually by column. Cells are randomly subsampled to the same number of cells in each sample. b–e, Comparison of SSC vs. CD45 (left plots) to MD axes (right plots) for the four patient samples, with populations shaded according to the key between the plots. f, Neoplastic blasts and mature myeloids (monocytes and neutrophils) from the four samples in D on MD axes, colored by sample (left). Density plot of MD2, which largely tracks monocyte differentiation, colored by sample (right).
