Extended Data Fig. 7: Putative upstream drivers highlight variable response dynamics and cell-cell signaling.
From: Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
a, Median gene set scores for significantly temporally variant (p < 0.05) upstream drivers in all participants. Gray boxes indicate that the upstream driver was not significantly variant in that cell type and participant. Right-Tailed Fisher Exact Test; see Supplementary Table 2 for cell numbers per timepoint per cell type. b, Putative cell-cell network described in Fig. 3j, but all nodes and connections depicted. Nodes represent genes with either measured upregulation in the modules in Fig. 3e–i or predicted drivers from IPA. Edges were drawn from connections nominated by IPA and curated from the literature.
