Extended Data Fig. 8: Two cases of similar temporal modules in NK cells and monocytes: variable correlation and variable co-expression.
From: Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
a, Module scores in NK cells for NK GM3 and NK GM4 in P3. Ellipses drawn at 95% confidence interval for cells from each timepoint. See Supplementary Table 2 for cell numbers per timepoint. b, Correlation (spearman’s rho) between the scores for NK GM3 and NK GM4 at each timepoint. Two-sided asymptotic t approximation; FDR corrected q-value: N.S = not significant; *q < 0.05; ** q < 0.01, *** q < 0.001. c, Gene expression heatmap of all NK cells in P3 for those genes in NK GM3 and NK GM4. Cells are separated based on k-means (k=3) over the depicted genes. d & e, Same as in a & b but for monocyte modules Mono GM1 and Mono GM3 in P3. f, Gene set enrichment analysis of the genes in Mono GM1 and Mono GM3 against the following MSigDB collections: Hallmark, C2, C3, C5, and C7. FDR corrected hypergeometric test; number of genes: GM1 - 33, GM3 - 52.
