Extended Data Fig. 4: Difference in age at disease onset estimates by sex, across polygenic risk score categories (FinnGen, n = 135,300).

CHD = coronary heart disease, AF = atrial fibrillation or flutter, T2D = type 2 diabetes. The estimands are restricted mean survival times (RMST) for age at onset, and the error bars represent their 95% confidence intervals. Incident and prevalent cases included. All tests were two-tailed.