Extended Data Fig. 3: B7-H3 CAR T cells are highly potent against ATRT PDXs in vivo. | Nature Medicine

Extended Data Fig. 3: B7-H3 CAR T cells are highly potent against ATRT PDXs in vivo.

From: Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

Extended Data Fig. 3

a, Representative IHC image of B7-H3 staining of IC-pPDX-69 and IC-pPDX-159 ATRT PDX after engraftment (IC-pPDX-69: H Score 210 and IC-pPDX-159: H score 210). Staining was performed one time. b, Experimental overview for the evaluation of in vivo efficacy of B7-H3 CAR T cells against IC-pPDX-69 c,d, and IC-pPDX-159 e,f, Summary (c,e) and individual (d,f) tumor measurements after 10x106 B7-H3 CAR T cells or CD19 CAR T cells (control) (c) p = 2x10-6; (e) p = 6x10-5 (Two-way Anova). All data are means ± s.e.m. Experiment has been performed one time (n = 10 mice per group).

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