Extended Data Fig. 4: Locoregionally administered B7-H3 CAR T cells are highly potent against orthotopic ATRT xenografts in vivo. | Nature Medicine

Extended Data Fig. 4: Locoregionally administered B7-H3 CAR T cells are highly potent against orthotopic ATRT xenografts in vivo.

From: Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

Extended Data Fig. 4

a, Representative IHC image of B7-H3 staining of BT12 ATRT xenograft (H Score: 270). Staining was performed one time. b, IT Group (B7-H3 (1x106) and CD19 (1x106) CAR T cells), c, ICV Group (B7-H3 (1x106) and CD19 (1x106) CAR T cells), d, IV Group (1x106 or 10x106) B7-H3 and CD19 (10x106) CAR T cells). (c-e) Bioluminescence (BLI) was obtained serially and flux curve for individual mice are shown. Kaplan-Meier analysis (n = 1) of B7-H3 or CD19 (control) CAR T cell treated mice (IT p = 0.0023; ICV p = 0.0031); IV (1x106) p = 0.6015; IV (10x106) p = 0.0038). (Log-rank (Mantel-Cox) test, two-tailed). One mouse in the B7-H3 (10x106) IV group died while imaging and was censored from analysis. Mio=million.

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