Extended Data Fig. 6: Association between IL-8 expression and TMB in human malignancies. | Nature Medicine

Extended Data Fig. 6: Association between IL-8 expression and TMB in human malignancies.

From: Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

Extended Data Fig. 6

Association between IL-8 mRNA expression and TMB in human Mel (a, n = 324), RCC (b, n = 291), nsqNSCLC (c, n = 427), and sqNSCLC (d, n = 382) from TCGA cohort. The levels of IL-8 transcripts are presented as log10 transformed FPKM units. TMB level was determined as previously reported, including both nonsynonymous and synonymous variants. Dots represent individual samples. Linear regression lines are indicated by purple lines within each chart. IL, interleukin; FPKM, kilobase per million mapped reads; Mel, melanoma; nsqNSCLC, nonsquamous non-small cell lung cancer; RCC, renal cell carcinoma; sqNSCLC, squamous NSCLC; TMB, tumor mutational burden.

Back to article page