Extended Data Fig. 5: Comparison of the in vivo protective capacity of mAbs 4493, 317, and CIS43.

a, Capacity of mAbs 317¹⁸, CIS43²³, 4493 and 1210²⁵ to protect mice from blood-stage parasitemia after passive i.p. mAb transfer (300 µg/mouse) and exposure to the bites of mosquitoes infected with Pb-PfCSP parasites. The percentage of parasite-free mice is indicated. The C-CSP-reactive non-inhibitory mAb 1710 (ref. ²¹) was used as negative control. Pooled data from two independent experiments is shown (N=2). The total number of mice per group is indicated (n). Statistical analyses were performed using Mantel-Cox log-rank test. Groups labeled with the same letter were not statistically significantly different. Groups labeled with different letters were statistically significantly different. b, Serum concentration of the transferred monoclonal antibodies in individual mice at the time of parasite challenge. Data shows the mean of at least two independent measurements. Red bars indicate mean values.