Extended Data Fig. 1: A low proportion of MerTK^posCD206^pos STMs in remission was associated with increased risk of disease flare after treatment cessation.

a–d, Comparison of STM distribution between RA patients with disease remission defined by either DAS28 (n = 24) or Boolean criteria (n = 11). Analyses include comparison of STMs: a, single-marker positive or negative for CD206 or MerTK or CD163, b, double-marker positive or negative for MerTK and CD206, and double-marker positive or negative for CD206 and CD163, c, double-marker positive or negative for MerTK and CD163 and (d) triple-marker positive for MerTK, CD206 and CD163. e-i, Comparison of baseline STM distribution between RA patients in remission who subsequently flared (n = 11) or remained in remission (n = 11) after treatment discontinuation. Analyses include comparison of STMs: e, single-marker positive or negative for CD206 or MerTK or CD163, f, double-marker positive or negative for either MerTK or CD206, g, double-marker positive or negative for either CD163 or CD206, h, double-marker positive or negative for either MerTK or CD206 and (i) triple-marker positive for MerTK, CD206 and CD163. j, ROC curves for optimal cut-off values of STM proportions of CD206^pos, MerTK^posCD206^pos, MerTK^negCD206^neg, CD163^posCD206^pos, CD163^negCD206^neg, and the MerTK^posCD206^pos to MerTK^negCD206^neg ratio discriminating disease flare in RA in remission (n = 22) described in e-i. (Wilson/Brown method) k, Comparison of occurrence of flare stratified by the cut-off values for different STM populations (Wilcoxon test.) Data in (a-i) are mean + /-sem, differences in STM populations between remission states were evaluated by Two-tailed Mann-Whitney, p-values provided on graphs.