Extended Data Fig. 2: Metformin’s effects on NSC pool recovery following juvenile cranial radiation are not sex-dependent. | Nature Medicine

Extended Data Fig. 2: Metformin’s effects on NSC pool recovery following juvenile cranial radiation are not sex-dependent.

From: Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

Extended Data Fig. 2

a, b, Fold change in the number of neurospheres from the SVZ 5 weeks post-radiation in (a) females (n = 8 Ctrl, 9 IR, 6 IR + Met mice over 6 independent experiments; F(2,20) = 0.56, p = 0.58) and (b) males (n = 9 Ctrl, 7 IR, 12 IR+Met mice over 6 independent experiments; F(2,25) = 0.03, p = 0.97). (c-d) Fold change in the number of neurospheres from the DG 5 weeks post-radiation in (c) females (n = 6 Ctrl, 5 IR, 6 IR+Met mice over 4 independent experiments; F(2,14) = 3.47, p = 0.06; Ctrl vs. IR, p = 0.0496) and (d) males (n = 4 Ctrl, 5 IR, 4 IR+Met over 4 independent experiments; F(2,10) = 6.47, p = 0.02; Ctrl vs. IR, p = 0.04; IR vs. IR+Met, p = 0.02). *p < 0.05, one-way ANOVA with Tukey’s test was used for all analyses. Data is presented as mean ± SEM.

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