Extended Data Fig. 3: Cranial radiation does not lead to impairments in the open field test or in the elevated plus maze. | Nature Medicine

Extended Data Fig. 3: Cranial radiation does not lead to impairments in the open field test or in the elevated plus maze.

From: Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin

Extended Data Fig. 3

a, Experimental paradigm. IR=cranial radiation. b, c, Path length travelled over 10 minutes in an open arena by (b) females (n = 17 Ctrl, 15 IR, 13 IR+Met mice over 13 independent experiments; F(2,42) = 0.62, p = 0.54) and (c) males (n = 17 Ctrl, 19 IR, 19 IR+Met mice over 13 independent experiments; F(2,52) = 0.40, p = 0.67). d, e, Percentage of time spent in the open arms of the elevated plus maze over 10 minutes by (d) females (n = 5 Ctrl, 5 IR, 6 IR+Met mice over 4 independent experiments; F(2,13) = 1.26, p = 0.32) and (e) males (n = 5 Ctrl, 5 IR, 6 IR+Met mice over 4 independent experiments; F(2,13) = 0.78, p = 0.48). One-way ANOVA with Tukey’s test was used for all analyses. Data is presented as mean ± SEM.

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