Extended Data Fig. 4: Consort table.

Eligible participants were identified via database review. Randomization was conducted by the Research Support Pharmacy and all research personnel remained blind to treatment assignment until all participants had completed the trial and data processing and scoring was completed. Initially, due to the pilot nature of the trial, neuroimaging and neuropsychological assessments were acquired at three time points (Baseline 1 and 2; Outcome 2). With an amendment to the study protocol, subsequent participants were assessed at four time points (Baseline 1 and 2; Outcome 1 and 2). Therefore, fewer Outcome 1 than Outcome 2 data points were acquired. Linear mixed modeling can be used in the context of such missing data. The single participant who consented but did not complete the trial was not included in the analyses.