Extended Data Fig. 9: Reproducibility of drug toxicity assay of PHH cells under LCA pretreatment.
From: Polygenic architecture informs potential vulnerability to drug-induced liver injury
a–c, Drug sensitivity comparison between different days’ experiments under LCA pretreatments. (a) HUM4133. (b) HEP187269. (c) HEP187277. d–f, Drug sensitivity comparison between different days’ experiments under none pretreatments. (d) HUM4133. (e) HEP187269. (f) HEP187277. (g, h) Viability comparison of multi-donor iPSC-HLO models under the indicated CsA treatment without LCA. Pearson’s r for correlation with PRSgw (g) or PRSgw+ h), and its P-value is described. *, p<0.05. We regress mean viability for each donor by PRSgw or PRSgw+ and calculated the P-values.
