Extended Data Fig. 2: TAK-875 DILI severity and GWAS analysis.
From: Polygenic architecture informs potential vulnerability to drug-induced liver injury
a, Ratio of ALT, AST, and BILT peak values to their basal values. b, Distribution of time from start of drug to DILI onset (days). c, Exclusion criteria of TAK-875 samples based on genetic ancestors. d, The outlier of TAK-875 samples was not observed in Northern Europeans from Utah (CEU), Tuscans from Italy (TSI) and Mexican (MEX) ancestry. e, Quantile-Quantile plot for the TAK-875 GWAS. f, g, Polygenic test using hepatocellular DILI-GWAS summary statistics in (a) and All DILI-GWAS ones in (b). X-axis, the total number of SNPs, ordered by iDILIC/DILIN GWAS association; y-axis, explained the variance of TAK-875 white GWAS; color scale, p-value for the shared genetic aetiology analysis.
