Extended Data Fig. 2: Mutational Landscape of High-Risk Paediatric Cancers.

An oncoprint of the reportable germline and somatic events, of any type, observed in more than 2 patients. Genes are classified into broad pathway categories and ordered by the percentage of patients harbouring an alteration in the specified gene. The barplot above shows the number of events in each patient highlighted by aberration type. The barplot on the right shows the total number of events in each indicated gene, highlighted by aberration type and represents genes where more than one aberration, for example CNV gain and over-expression, occurred in the same sample. Where individual genes are shown for each patient, the colour represents the variant type (legend shown on right). Where these bars have multiple colours, it is because the same variants were detected by different techniques, or there are multiple variant types affecting each allele. The heatmaps on the bottom show the distribution of cancer type, stage of disease and sex of patient (legend shown on the right).