Extended Data Fig. 4: Markers of response to immunotherapy were not associated with CR. | Nature Medicine

Extended Data Fig. 4: Markers of response to immunotherapy were not associated with CR.

From: Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i

Extended Data Fig. 4

Baseline T-cell–inflamed GES levels and TMB in samples from patients with and without a CR. For T-cell–inflamed GES: n = 27 independent tumor biopsy specimens (CR, n = 14; no CR, n = 13). For TMB: n = 24 independent tumor biopsy specimens (CR, n = 12; no CR, n = 12). Box plots show median, first and third quartiles (boxes), and range up to 1.5 times IQR from the bounds of the box [whiskers]. Points beyond 1.5 times IQR from the bounds of the box are plotted individually. For T-cell–inflamed GES: CR, 4.90 (4.31-5.27) [3.48-6.09]; no CR, 4.87 (3.99-5.30) [2.88-6.65]. For TMB: CR, 7.196 (5.957-9.205) [3.365-13.479]; no CR, 7.209 (6.639-9.140) [3.539-10.533]. Descriptive P values are based on a two-sided Wilcoxon rank sum test (T-cell–inflamed GES: W = 89, effect size -0.04 [95% CI, -0.75-0.83]; TMB: W = 79, effect size 0.05 [95% CI, -2.40-2.85]); no adjustments were made for multiple comparisons. CPM, counts per million; CR, complete response; GES, gene expression signature; IQR, interquartile range; TMB, tumor mutational burden.

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