Extended Data Fig. 6: Differential expression analysis of DARA-KRD resistant patients. | Nature Medicine

Extended Data Fig. 6: Differential expression analysis of DARA-KRD resistant patients.

From: Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

Extended Data Fig. 6

a, Volcano plot showing a selected set of differential genes between PRMM responder group and PRMM non-responder group. X axis showing the difference between the average z-score of PRMM responder group and PRMM non-responder group; Y axis showing the log10 p-value from a bootstrap test using t-statistic (Methods). b, Scatter plot on the left showing the overlap between gene module 1 in Fig. 2a and resistance signature 1 in Fig. 4a. X axis showing the difference between the average z-score of NDMM patients and PRMM patients; Y axis showing the difference between the average z-score of PRMM responder group and PRMM non-responder group. Scatter plot on the right showing the same as the left one, but for gene module 3 and resistance signature 2. c, Venn diagram showing the overlap between the PRMM patient groups classified in Fig. 2a and PRMM responder and non-responder groups.

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