Extended Data Fig. 3: The robustness of differential expression z-score. | Nature Medicine

Extended Data Fig. 3: The robustness of differential expression z-score.

From: Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

Extended Data Fig. 3

a, comparison of standard log2 fold change vs. our z-score for patient KYDAR 24 clone 1 relative to healthy control. Size of the dots corresponds to the mean expression (UMIs) in the healthy control samples. b, Scatter plot showing the -log10 p-value from the two-sided Mann-Whitney test and the z-score. c, scatter plot comparing our z-score to variance/mean showing no clear bias with high z-score and cell-cell variability. d, z-score scatter plots comparing different sub-sampling of cells (100, 400 and 800 cells). e, z-score scatter plots comparing different sub-sampling of UMIs per cell (300, 400 and 500 cells). f, The distribution of the z-score from patient KYDAR 24.

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