Extended Data Fig. 9: Amount of effect mediated from a risk factor onto an outcome through a specific metabolite.
From: Plasma metabolites to profile pathways in noncommunicable disease multimorbidity
Heatmap of risk factor—metabolite pairs with a significant indirect effect of the risk factor on at least one of the diseases under investigation. Colouring was done based on the median proportion mediated by a metabolite across all diseases. The proportion mediated was derived as quotient of the main effect from two different Cox proportional hazed models, one with and one without adjusting for the metabolite and both including the risk factor as main exposure. Boxes indicate corrected statistical significance with at least one disease (p < 0.05/6,364) and grey shades indicate not tested due to missing requirements for mediation analysis.
