Extended Data Fig. 10: Vision for clinical translation of the PerMed.
From: A perfusable, multifunctional epicardial device improves cardiac function and tissue repair
a, Schematic of the design and components of the PerMed equipped with the claw-shaped fixator. b, Design of the claw-shaped fixators with components of different types and sizes. The claw-shaped fixator consisted of a middle ring and three or four lateral arms with barbs (i, ii). The height of the arms was 4.0, 4.5, 5.0 and 6.0 mm (iii, iv); ‘h’ indicates the length of the arm, ‘w’ indicates the width of the arm, and ‘r’ indicates the diameter of the middle ring. c, Schematic of the clinical application of the PerMed. T1 indicates trocar 1; T2 indicates trocar 2; T3 indicates trocar 3. d, Schematic of the process of minimally invasive surgical implantation of the PerMed under thoracoscopic guidance, including compression of the PerMed (i), delivery of the PerMed through T2, stretching of the PerMed (iii), anchoring of the PerMed onto the surface of the porcine heart (iv, v) and extraction of the outer sheath (vi). Purple rings indicate the location of the PerMed. e, Image of the PerMed used in the porcine heart (3 cm in diameter and 2 mm in thickness). f, Top view of the PerMed anchored onto a porcine heart(i), closure of the pericardium, and conformability of the PerMed to the porcine heart (iii), n = 3 independent experiments.
