Fig. 2: SARS-CoV-2 501Y.V2 increased resistance to neutralization by convalescent plasma/serum.
From: SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
Plasma/serum collected from individuals infected with SARS-CoV-2 was assessed for neutralization to the original lineage (Wuhan-1 D614G, left), an RBD chimeric mutant containing K417N, E484K and N501Y substitutions only (middle) or the 501Y.V2 lineage pseudovirus. Twelve of the samples were collected from donors hospitalized for >10 d with COVID-19 (black). The graph is colored according to the magnitude of neutralization titer, with ID50 greater or lesser than 1:400 colored dark or light blue, respectively and titer <100 colored orange. The limit of detection (knockout) was an ID50 < 20 (red). Pie charts above each set of data points summarize the proportion of samples in each titer group.
