Extended Data Fig. 8: Prognostic value of SPP1 and COL6A1 proteins in plasma of ALS patients within individual country cohorts.
From: Altered perivascular fibroblast activity precedes ALS disease onset
a, SPP1 (HPA027541), (b) SPP1 (HPA005562) - technical valifdation antibody and (c) COL6A1 (HPA01914). Relative levels of protein levels in ALS patients and age-matched controls. Red color indicates thresholded protein level. Automated threshold selection using maximally selected log rank statistics. Boxplots show median, 2nd-3rd quartile and whiskers show ±1.5 of the IQR. COL6A1 protein values in the Belgian cohort did not indicate an optimized threshold and were separated at the median value. Kaplan-Meier survival estimate of high and low protein groups with two-tailed K-M logrank test p-values.
