Extended Data Fig. 4: COL6A1 and SPP1 proteins accumulate in enlarged perivascular spaces in sporadic ALS patients’ spinal cords.
From: Altered perivascular fibroblast activity precedes ALS disease onset
a, Two-color histochemistry for COL6A1 or SPP1 (red) relative to mural basement membrane outlined with COL6A1 (blue). Four sporadic ALS cases are represented with non neurological control spinal cords, bar: 100 μm. b, Correlation of SPP1 and COL6A1 histochemistry with pathological scores for GFAP, HLA-DR and motor neuron (MN) loss. Spearman test R-rho and two-tailed p-vales are indicated in each graph.
