Extended Data Fig. 5: Basement membrane gene ontology groups are enriched in presymptomatic stages of ALS.
From: Altered perivascular fibroblast activity precedes ALS disease onset
Enrichment of gene sets from gene ontology groups (basement membrane - GO 0005604, basement membrane organization - GO 0071711 and collagen metabolic process - GO 0032963) in sporadic ALS patients and SOD1G93A mice. Significantly regulated genes are shown as red circles (○). Mroast test analysis from the limma R package. Multiple test (FDR) adjusted gene expression enrichment is shown as blue bar. p - FDR adjusted two-tailed mroast test p-value.
