Extended Data Fig. 5: Individual fit to stereotypical subtype progression.
From: Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Individual fit to stereotypical subtype progression. a) Progression plots are created for each subtyped individual based on their progression through events specific to their subtype. The outer images show regional tau z scores (see Extended Data Fig. 1) for an S2 (left) and S3 (right) individual. This data is summarized in lobar ROI z-scores (inner images). In progression plots under the images, each box represents a biomarker event, SuStaIn stage. A SuStaIn stage represents tau reaching a given severity (Z) score at a given region (see Extended Data Fig. 1). Filled (boxes indicate an individual fulfills the criteria for that SuStaIn stage. An empty (black) box indicates an individual does not. Note that each subtype has a different event order. b) A stepwise progression plot is shown for each subtype. Each row represents an individual, and each column represents SuStaIn stage. A perfect fit would be represented by an individual (row) having every box filled before a given stage, and no boxes filled after. y-axes (subjects) are sorted from the least (top) to most (bottom) stages fulfilled. Across the population, this should be represented as a stepwise progression. Each subtype demonstrates a stepwise progression indicating good general fit. The average subject fit imperfection was 2.1 boxes.
