Extended Data Fig. 9: Lateralization across disease progression as measured with SuStaIn stage.
From: Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Lateralization across disease progression as measured with SuStaIn stage. a, Tau lateralization was measured as the mean left to right ratio of scores for all ten tau features. Higher positive numbers represent greater left hemisphere tau lateralization, whereas lower negative numbers represent greater right hemisphere lateralization. The progression of laterality over SuStaIn stage was visualized for each subtype. Lateralization generally increased with increasing SuStaIn stage. In some subtypes (particularly S2 and S3), strong lateralization was seen in both hemispheres later stages. b, The absolute (that is agnostic to hemisphere) lateralization was visualized against SuStaIn stage, indicating general increase in lateralization with more severe tau expression. c, A three-way relationship between age, SuStaIn stage and absolute lateralization is visualized, indicating these relationships covary but are independent of one another. For b, confidence interval represents 95% around line-of-best-fit across 1000 bootstrap samples.
