Extended Data Fig. 10: Replication of subtype-specific epidemic spreading model.
From: Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Replication of subtype-specific epidemic spreading model. We repeated analyses from Fig. 4, this time using functional connectivity from a sample of elderly healthy and MCI individuals, over a higher-resolution cortical atlas, as the connectome input to the model. The ESM was fit separately for each subtype; once using an entorhinal cortex epicenter (a), gray], and once with a subtype-specific best-fitting epicenter (b), blue]. For each plot, each dot represents a region. The x-axis represents the mean simulated tau-positive probabilities across the population, while the y-axis represents mean observed tau-positive probability. Each column represents a subtype. Confidence interval represents 95% CI around line-of-best-fit across 1000 bootstrap samples c) Visualization of the best-fitting epicenter selected by the model. d) For each subtype, the probability that each region’s best fitting epicenter for that subtype, based on bootstrap resampling (1000 samples).
