Extended Data Fig. 2: Most frequent DNA alterations from archived tissue.

Common alterations: Mutations: 65% TERT promoter, 59% TP53, 36% KMT2D, 27% KDM6A and 23% KMT2C. Copy number alterations: 31% CDKN2A loss, 31% CDKN2B loss, 12% MDM2 amplification, 12% FRS2 amplification, 11% CCND1 amplification.