Extended Data Fig. 2: Mutational Spectrum Profile of Common Ancestor.

489 common single nucleotide variants (including non-coding mutations) found in all tumors with mutations called individually in each sample are represented in their tri-nucleotide context; this mutational spectrum has cosine similarity of 0.965 with the ultraviolet DNA damage signature (Signature 7; https://cancer.sanger.ac.uk/cosmic/signatures). A similar analysis with 548 common ancestor mutations inferred jointly by PyClone generates similar results with cosine similarity of 0.962 to the UV signature (not shown).