Extended Data Fig. 5: Hierarchical Clustering of Mutational Clusters CCFs and Copy Number Alterations define concordant tumor lineages.
From: Evolution of delayed resistance to immunotherapy in a melanoma responder
Top: Hierarchically clustered heatmap of inferred cancer cell fractions (CCFs) for each mutation cluster (columns) for each tumor (rows), demonstrating 7 different lineages. Bottom: Hierarchically clustered heatmap of large copy number alterations (columns) for each tumor (rows), demonstrating concordance with lineages derived from mutational clusters. Complete allelic deletions are dark blue, and copy number gains and losses are light blue.
