Extended Data Fig. 2: Immune cell composition of the liver in NASH development.
From: XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis
a, Heat map of differential gene expression for all cells colored by the assigned metacells as in Fig. 1. Top bar graph shows relative contribution of ND and MCDD liver immune cells to each metacell. b, Density plots depicting distribution of cells in ND and MCDD condition (downsampled to 6699 cells) and enrichment analysis of MCDD as compared to ND (all time-points analyzed together) projected on the kNN graph. Red areas represent enrichment, blue areas represent depletion. c, kNN graph of liver immune cells of wild-type mice kept on ND and MCDD, down-sampled to 1000 cells at each time-point analyzed. d, relative abundance of immune cell subtypes in livers of ND or MCDD-fed wild type mice at each analyzed time-point.
