Extended Data Fig. 4: Validation of microbial composition and response taxa across additional datasets.
From: Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
a, Ordination of microbial beta diversity contrasting compositional differences between responders (R, n = 59) and non-responders (NR, n = 24) across the pooled CICB and previously published anti-PD-1 monotherapy (Science 2018) cohorts (Weighted UniFrac, PERMANOVA two-sided p = 0.002). b, Abundance of key response-associated taxa identified in the CICB cohort were evaluated in re-processed microbiome data from several published cohorts, indicating taxa enriched in responders (blue), taxa enriched in non-responders (red), or not detected (white) in each cohort by two-sided Mann-Whitney test (Ruminococcus; Gopalakrishnan, Science 2018 one-sided p = 0.0240, Frankel, Neoplasia 2017 one-sided p = 0.0487).
