Extended Data Fig. 3: Humoral immune response against all SARS-CoV-2 variants following homologous BNT162b2 (BNT) / BNT162b2 (BNT) vaccination.
a,b, Spike-specific IgG (a) and IgA (b) levels in plasma after prime (open circles) and 30 days (mean) after booster (closed circles) homologous BNT/BNT vaccination. Data are from n = 16 biologically independent sample pairs. c, Reciprocal titers of neutralizing antibodies against Wuhan-Spike, B.1.1.7-Spike (Alpha), P.1-Spike (B.1.1.28.1; Gamma), and B.1.351-Spike (Beta) SARS-CoV-2 variants measured using surrogate virus neutralization test (sVNT). Data are from n = 30 biologically independent sample pairs. For better visualization of identical titer values, data were randomly and proportionally adjusted closely around the precise titer results. Statistics: a-b. Paired t-test (within groups); c. Chi-square test for trend. a-c, Dots represent individual vaccines, lines represent group median.
