Extended Data Fig. 7: Longitudinal tau propagation network correlations.
From: Microglial activation and tau propagate jointly across Braak stages
The plots show the correlations across PET Braak-like regions used in the longitudinal tau network analysis presented in Fig. 3A. P values reflect the results of two-sided Pearson’s correlation between changes in [18F]MK-6240 SUVR corrected for age, sex, education, APOE ε4 status, and the changes in the remaining Braak regions not used in the given correlation. A correlation was interpreted as significant if it survived Bonferroni correction for multiple comparisons (15 tests, P < 0.0034). ** indicates a significant positive correlation (n = 56, 34 CU (6 males, mean age = 73 (6)), 13 MCI (9 males, mean age = 74 (6)), and 9 AD dementia (4 males, mean age = 70 (7)).
