Extended Data Fig. 2: Patient demographics and clinical characteristics.

*An additional stage IVM1c patient was determined to be ineligible after going on study. †Arm 1 immunotherapies include pembrolizumab for one patient, ipilimumab for one patient, and interferon for one patient. Arm 2 immunotherapies include pembrolizumab for one patient and ipilimumab for two patients. ‡Arm 1 n = 76, Arm 2 n = 73. §Arm 1 n = 62, Arm 2 n = 59. CRF = case report form; ECOG = Eastern Cooperative Oncology Group; IVRS = interactive voice response system; SPD = sum of products of two largest perpendicular diameters of baseline measurable lesions; T-VEC = talimogene laherparepvec.